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KMID : 1007020060040010028
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Korean Soceity of Osteroporosis
2006 Volume.4 No. 1 p.28 ~ p.35
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Clinical Implication of Biochemical Bone Markers in the Management of Postmenopausal Osteoporosis
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Shin So-Young
Yoon Byung-Koo
Kim Ji-Young
Shin Kyung-Ja
Kim Joo-Han
Min Yong-Ki
Choi Doo-Seok
Bae Duk-Soo
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Abstract
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Objectives: To assess the clinical significance of baseline levels of and short-term changes in biochemical markers of bone turnover with hormone therapy(HT) in predicting changes in bone mineral density (BMD) in Korean postmenopausal women.
Methods: We studied 238 healthy postmenopausal women. Eighty women took HT for 2 years and 158 remained untreated. At baseline and month 3, concentrations of serum osteocalcin(OC) and urinary deoxypyridinoline(D-pyr) were checked as a marker of bone formation and resorption, respectively. BMDs at both lumbar spine and femur were measured at baseline and years 1 and 2.
Results: In untreated women with high D-pyr level(≥6nM/mM Cr) at baseline, more bone loss(% change, mean±SEM) at total hip was observed at year 2 compared with those with normal D-pyr (-2.0 0.7 vs. 0.5±5.5, P＜0.05). There was a positive correlation between baseline OC level and BMD change in lumbar spine at year 2 in HT group(r=0.23, P＜0.05). However, no significance correlation was found between changes in bone markers at month 3 and those in BMD at year 2 in HT group. BMD changes at year 2 were also comparable according to response pattern to HT at month 3 in women with high bone turnover at baseline
Conclusions: Basal measurements of biochemical bone markers might be useful in predicting BMD change at year 2. However, follow-up measurement at 3 months of HT has limited usefulness in predicting treatment response.
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KEYWORD
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Osteoporosis, Biochemical markers, Bone mineral density, Hormone therapy
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